Monday, August 11, 2014

Politex Product Information


Polilex spray is manufactured in an FDA approved facility in Switzerland. In human studies, Polilex (aka Metadichol®) which contains Policosanol Nanoparticles has shown to be very effective in strengthening the immune system by modulating the nuclear receptors in the nucleus of the cell and thus assisting the body in preventing and fighting diseases, in reducing insulin resistance, and in healing itself. Our studies have shown that Polilex targets and improves key biomarkers implicated in diabetes, hyperlipidemia, obesity, cardiovascular disease, cancer, kidney disease, inflammation and auto immune diseases. Unlike prescription drugs, Polilex is a natural, non-toxic food supplement that has no known side effects. All its ingredients are classified by U.S. FDA as a GRAS (generally regarded as safe) product.

The nanoparticles in Polilex have unique aerodynamic and biochemical properties that affect the immune system and human health in ways that are different from those seen with gases or larger particulates. These effects result from a unique set of physical characteristics and surface moieties, which generate an ability to enter tissues and cells, interact with proteins and DNA at a molecular level and directly or indirectly modulate the immune system.

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When particles enter the bloodstream, their sizes dictate the organs they are likely to become trapped in. Particles larger than 3,000 nm may end up in the lungs, particles larger than 300 nm in the spleen, and particles larger than 100 nm in the liver. Polilex’s policosanol nanoparticles are less than 60 nm in diameter, therefore fewer of them would end up being trapped in the organs and more of them are able to circulate through the bloodstream until they reach a targeted cell. Nanoparticles are more stable, provide a higher precision of delivery to targeted tissues and cells, and are more effective in improving the immune health.

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The Polilex Story
Polilex is made from food ingredients that are formulated in water. It is designed to bind to Vitamin D receptors and serve as a substitute for 1.25-Dihydroxy-Vitamin D3 which is endogenously produced by sunlight. In human studies, Polilex (aka Metadichol®) has shown to be very effective in treating insulin resistance and diabetes (types I & II), increasing vitamins C and adiponectin levels, reducing blood pressure, protein oxidation, NF-κB protein, TNF protein and ICAM-1 levels, and regulating blood sugar, VLDL (very low density lipids), C-reactive protein, nitric oxide, albumin/globulin ratio, glutathione, PAI-1, and MCP-1 levels. Therefore, directly or indirectly, Polilex could help in treating or preventing diseases associated with an imbalance of these vitamins, proteins and biomarkers.
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Vitamin D
Along with the 10 trillion (10 to the 13 power) cells in a human body, there are trillions of VDR (Vitamin D Receptors). Therefore sufficient Vitamin D is essential to support healthy cell and immune functions. A healthy immune system could activate microphages and killer T cells to defend against invading viruses.
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Norman A. published the following diagram in Annals of Nutrition & Metabolism, 2012;61(3):199-206 to demonstrate the contributions of Vitamin D to support the six physiological systems and good health.

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1,25-Dihydroxy-Vitamin D3 affects over 2000 genes in the human body. Under normal physiological and environmental circumstances, the human body can generate significant quantities of vitamin D3 to meet its nutritionally defined requirements via ultraviolet exposure of 7-dehydrocholesterol present in the skin. However, in modem life-style and work environment, most people are confined indoor in air conditioned buildings during working hours and do not have sufficient exposure to ultraviolet light. Even at outdoor, many people would wear hats or carry umbrellas to shield themselves from sunlight. And for those who like the beach and sun bathing, the sunscreen they apply would prevent them from absorbing UV B rays that produce Vitamin D. Therefore, Vitamin D deficiency has become a norm for the modern generation and the prevalence of Vitamin D deficiency associated diseases, as indicated in the above picture, has been on the rise.

Each spray of Polilex contains more than 1018 to bind to the VDR. Therefore, Polilex has the ability to serve as a substitute for 1,25-Dihydroxy-Vitamin D3, provide normal biochemical cell function, and help to treat or prevent diseases associated with Vitamin D deficiency. (10 to the 18th power) of policosanol nanoparticles which are specially designed

Vitamin C
Medical researchers have known that heart disease, insulin resistance, diabetes, scury and many other health problems are accompanied by a decrease in serum vitamin C. Unfortunately, orally administered supplemental vitamin C is found to be ineffective and does not improve endothelial dysfunction or insulin resistance.
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Polilex has the ability to increase serum vitamin C and reduce the risk for insulin resistance, diabetes and other health problems associated with a low level of vitamin C.

In a 60-week clinical study of 14 patients (7 males and 7 females) with Metabolic Syndrome treated with Polilex (Metadichol® 0.5%), the average vitamin C level increased by 21% at Week 12 and 100% at Week 60.
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Adiponectin
Adiponectin is a protein hormone that modulates a number of metabolic processes including glucose regulating and fatty acid catabolism. Diseases associated with a decrease in Adiponectin are Metabolic Syndrome, type 2 diabetes, obesity, coronary artery disease, hypertension, non-alcoholic fatty liver disease and other health problems.
Polilex has the ability to increase the Adiponectin level and thus reduce the risk for metabolic syndrome, coronary artery disease and other diseases.
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NF-kappa B
Medical researchers have known that the activation of NF-κB has been implicated in many diseases and disorders including cancer, allergies, myocardial infarction, type 1 and type 2 diabetes, obesity, hypercholesterolemia, heart disease, stroke, Crohn’s disease, cerebral aneurysm, asthma, cystic fibrosis, kidney disease, liver disease, gut disease, skin disease, tuberculosis, arthritis, glaucoma, appendicitis, bowel disease, AIDS (HIV-1), autoimmunity, lupus, Parkinson disease, retina disease, Huntington’s disease, cataracts, and many other inflammatory diseases and disorders. For example, Kumar A, et. Al., published the following diagram in Journal of Molecular Medicine, 2004:82:434-448.
Polilex has the ability to inhibit the activation of NF-κB which can in turn treat or prevent diseases associated with NF-κB activation in the body.
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TNF Alpha
Medical researchers have known that TNF alpha promotes the inflammatory response which causes many of the clinical problems associated with autoimmune disorders (such as multiple sclerosis, eczema, rheumatoid arthritis, psoriasis), neurologic diseases (such as Alzheimer’s disease, epilepsy, bipolar disorder, depression), osteoporosis, cancer, non-alcoholic fatty liver disease, metabolic diseases, cardiovascular diseases and pulmonary diseases. For example, Aggarwal BB, et. Al., published the following diagram in Blood, Jan 2012:100(3):651-665.
Polilex has the ability to regulate and reduce the TNF alpha level which can in turn treat or prevent diseases associated with elevated level of TNF alpha in the body.
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The Human Genome
Medical researchers have known that much of the DNA in the human genome is organized into units called genes. The way the genes are arranged makes all the difference - one building block “misspelled” in a gene can cause disease.

Polilex has the ability to activate the Vitamin D Receptor (VDR), encoded by the VDR gene located on chromosome 12, to form a complex that binds to hormone response elements on DNA. This results in expression or repression of specific gene products and brings about the desired physiological changes and proper gene transcription.
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The protocol for Polilex is very simple:
For disease prevention and health maintenance, take 2-3 Polilex sprays once a day
For disease intervention, take 4-5 Polilex sprays twice a day. Monitor key biomarkers at baseline and at multiple time points after taking Polilex.

Polilex Results Tracking
Since no two individuals will have the same set of biomarker measurements and health condition, the best way to assess the effectiveness of Polilex is to obtain a set of baseline biomarker measurements (through blood test) before taking Polilex, and at multiple time points (say monthly) after starting on a daily dosage of Polilex. By tracking the key biomarkers, a medical professional will be able to assess the effectiveness of Polilex usage at each time point.
The time requires to correct an imbalanced biomarker is dependent on the health condition and the type and number of imbalanced biomarkers of each individual. In human studies, some patients showed immediate results after a few days. Some took a couple of months and some with more serious conditions took over a year.
Below is a list of biomarkers that are useful in assessing the effectiveness of Polilex. We recommend all users to get a baseline medical report with as many of these biomarkers as possible.
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FAQ

What is Polilex?
Polilex is a branded formulation of Metadichol® which contains Policosanol Nanoparticles. It is a natural food supplement with remarkable medical benefits. We have documented its effectiveness in patients with Hypertension, Diabetes (types 1 and 2), Obesity, Kidney Disease, and many other diseases (see Clinical and Case Study Results).

What are the ingredients in Polilex?
The primary ingredients in Polilex are water, vitamin E and Policosanol from rice wax.

What can Polilex do for the body?
Polilex serves as a substitute for vitamin D, helps to strengthen the immune system by modulating the nuclear receptors of the cell, reduces insulin resistance, and assists the body in preventing and fighting diseases and in healing itself.

What are the side effects of Polilex?
Polilex has no known side effects reported in human studies.

Is Polilex FDA approved?
The U.S. FDA only approves or disapproves pharmaceutical drugs. Polilex is a natural food supplement and cannot be classified as a drug. Therefore, it is not within the FDA’s responsibility to evaluate Polilex or other health supplements. All ingredients in Polilex are classified by FDA as a GRAS (generally regarded as safe) product.

Is Polilex recommended for healthy individuals or people with diseases?
Polilex can be taken daily by anyone as a health supplement to help strengthen the immune system and repair diseased cells. We have documented results on patients with cancer, kidney disease, hypertension, diabetes, obesity, thyroid and other diseases (see Clinical and Case Study Results).

When is the best time to take Polilex? Should it be taken with food or water?
Polilex can be taken at anytime of the day and with or without food and water.

When is the best time to take Polilex? Should it be taken with food or water?
Polilex can be taken at anytime of the day and with or without food and water.

Is it ok to take Polilex with prescription drugs or blood thinner?
There are no known interactions between Polilex and prescription medications.

Is Polilex safe for children and infants?
Yes, Polilex is safe for children and infants.

Is it safe to take Polilex during pregnancy?
Yes, Polilex is safe for pregnant women but talk to your physician.

What is the maximum daily dosage?
The recommended dosage is 2.5 to 5.0 mg per day. Toxic dosage is over 300,000 mg per day.

How can one measure the effectiveness of taking Polilex?
For people with diseases, the effectiveness of Polilex can be assessed by examining some key biomarkers (usually through blood test) before and at different time periods after taking Polilex (see Case Study Results and Polilex Results Tracking).

How long does it take to see positive results?
The time requires to correct an imbalanced biomarker is dependent on the health condition and the type and number of imbalanced biomarkers of each individual. In human studies, some patients showed immediate results after a few days. Some took a couple of months and some with more complicated conditions took over a year.


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